# Modeling the influence of channels on body functions

**Mathematical modeling level **

**Studying different kinds of pathology by drawing their average statistical portraits, based on databank samplings and correlation connections matrixes, we eventually get to an even higher level of generalization, which is building the models of channel regulating influences on different physiological parameters in the normal and pathological states. The research was conducted with the help of the regression analysis. The gist of the method is as follows. The test is carried out at the same time with registering some parameter, say, the heart rate. Then, a special mathematical program helps to find the channels, which are connected with the change of the heart rate through a certain coefficient. Thus, knowing the channels, which actually regulate certain parameters, their polarity marks and the regulating influence coefficient, it is possible to carry out prognosticated regulation of the necessary parameter by applying graduated action to the corresponding channel. On the other hand, certain channels’ testing data permits to calculate particular physiological parameter values, by substituting the channel activity figures into the model. In this way it is possible to calculate the heart rate, the arterial blood pressure, or a certain biochemical parameter, etc. Our further research is ideologically based on this universal logical principle of mathematical modeling.
If we have to deal with the pathologic syndrome, which cannot be measured directly, the method of the patient’s self-assessment within Robson’s 10-point scale can be used. For instance, if the patient has a splitting headache, he writes down the figure 10 in the questionnaire, if the headache is moderate the mark will be 5 points, if the patient doesn’t have any headache he puts 1 point. In this way, the patient’s subjective sensations are converted into numerical parameters, which permit to build his individual regulating model. We assess a subjective syndrome (a headache) on the basis of individual sensations. The models that we get by this method, in spite of their ‘subjectivism’, allow to make predictions, for example for Fisher’s F-criterion, which are from 70 to 90% accurate. The predictions’ accuracy level is often much higher, than of those, made with the help of “objective’ models.
Let’s consider some patterns of channel regulation with the help of such basic physiological parameters as the heart rate and the arterial blood pressure.
The examination of a group of 34 healthy men gave us the following formula of the heart rate (HR) regulation:
HR = 74 + 20 Cs – 26 Fd –12 Gis + 20 TRd (Rsq = 0,48), in which Cs is the left branch of the heart channel, Fd is the right branch of the liver channel, GIs is the left branch of the large intestine channel, TRd is the right branch of the triple heater.
The analysis of this formula shows that for men the hypo function of the left branch of the heart channel and the right branch of the triple heater results in the HR increase, while the hypo function of the right branch of the liver channel and the left branch of the large intestine channel results in the HR decrease. The liver and the large intestine channels control the volume of the deposited fluid in the liver and in the blood circulatory system; therefore they influence the HR in the opposite direction. They form a pole of the regulating dipole, opposite to the fire channels, at the ‘border layer’ level.
The examination of a group of 27 healthy women gave us the following formula of the heart rate (HR) regulation:
HR = 62 + 11Cd + 4VBd + 8GIs – 15 Es (Rsq = 0.53), in which VBd is the right branch of the gall bladder channel, Es is the left branch of the stomach channel.
Women’s regulating constant (62) has a lower value in comparison with the men’s one, as the bradysyndrome is more characteristic for them. The YANG channels are represented in the model only by the right branch of the heart channel (Cd). This branch of the heart channel exercises the most pronounced influence on the HR (let me remind you, that the left relates to YANG and the right – to ING). The GIs influence has changed its direction for the opposite one, and the left branch of the stomach channel has the biggest influence coefficient, which lowers the HR. It can be explained by the fact that food intake, in case of women, is often followed by bradycardia and hypotonia, and the general formula reflects it. Unlike it is with men, women’s ‘border layer’ channels, especially Es and GIs are very important for the HR regulation. The YANG channels influence coefficients’ total is -3, the ING channels influence coefficient is +11, which confirms the fact that ING normally domineers in case of women, while men’s models show the predominance of YANG influences. **